WP4 focuses on the interactions between tumour cells and stromal components mediated by proteases. Growing evidence indicates that cathepsins (B, L and D), ubiquitously expressed in epithelial, endothelial cells and leukocytes and frequently over expressed in cancer cells promote carcinogenesis and tumour-progression (Erkan et al 2008, Halangk et al 2000, Kukor et al 2002). Active forms mediate cell-death, tumour-angiogenesis, tumour-cell-proliferation and invasion. Other proteases such as tPA lie at the interface of the stroma and the tumour cells (Roda et al 2009). The major aim of WP4 is to determine the role of cathepsins for the prognosis of pancreatic cancer, their functional role in cancer-progression and, ultimately, the therapeutic efficacy of using them as a target.
Ernst-Moritz-Arndt-Universität Greifswald, Germany (EMAU-G)
Philipps-Universität Marburg, Germany (UNIMAR)
The University of Liverpool, United Kingdom (ULIV) per Participant
Fundación Centro Nacional de Investigaciones Oncologicas Carlos III (CNIO)
Technische Universität München, Klinikum rechts der Isar, Germany (TUM-MED)
Cancer Research UK, United Kingdom (CR-UK)