University of Liverpool
Department of Molecular and Clinical Cancer Medicine,
Daulby Street
L69 3GA, Liverpool

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Project leader

	Professor John Neoptolemos Phone: +44 151 706 4175 Fax: +44 151 706 5826 Email
	Dr William Greenhalf Phone: +44 151 706 4184 Fax: +44 151 706 5826 Email
	Dr Eithne Costello Phone: +44 151 706 4178 Fax: +44 151 706 5826 Email

Project staff

Dr Taoufik Nedjadi Phone: +44 151 706 4191 Fax: +44 151 706 5826 Email

Institute presentation

The Liverpool group (ULIV) come from The Department of Molecular and Clinical Cancer Medicine, The NIHR Liverpool Pancreas Biomedical Research Unit (Liverpool PBRU) and The Liverpool Cancer Research UK Centre.

ULIV conducts large Europe-wide pancreatic cancer trials, including the ESPAC trials of chemotherapy and chemoradiotherapy in the treatment of patients who have undergone surgery and the TeloVac Trial of a vaccine in combination with chemotherapy for advanced pancreatic cancer.

ULIV also co-ordinates the EUROPAC register which is the world’s largest collection of families with Hereditary Pancreatitis and Familial Pancreas Cancer. ULIV is currently working with these families to identify the underlying genetic cause of these diseases. Related work (a Europe-wide study called PANGEN) is attempting to identify how environmental and genetic factors interact to cause pancreatic cancer.

Systematic comparisons of protein expression profiles from highly purified specimens of pancreatic cancer and corresponding normal tissue, and blood from patients and healthy individuals have been undertaken to identify biomarkers. We take biomarkers from such basic laboratory research through to fully auditable analyses, conducted at the level of good clinical laboratory practice. This allows us to use samples from clinical trials to identify biomarkers for drug response.