To dissect the impact of inflammatory stromal components WP2 investigates the role of tumour-associated macrophages in coculture models in-vitro and elucidates the impact of macrophage-inhibition in genetically engineered mouse models. The role of immunomodulatory cells is investigated in a humanized immune-reconstituted (HIR) mouse model, hosting both the xenotransplanted bone-marrow derived immune system and the adenocarcinoma of the same pancreatic cancer patient. Therapeutic monoclonal antibodies and DNA vaccines are developed towards a selection of tumour antigens validated in human and engineered mouse models.

WP lead:

Philipps-Universität Marburg, Germany (UNIMAR)

WP members:

The University of Liverpool, United Kingdom (ULIV) per Participant
Fundación Centro Nacional de Investigaciones Oncologicas Carlos III (CNIO)
University of Verona, Italy (UNIVR)
Ernst-Moritz-Arndt-Universität Greifswald, Germany (EMAU-G)
Technische Universität München, Klinikum rechts der Isar, Germany (TUM-MED)
Bayer Schering Healthcare, Germany (BSP)
Fondazione Centro San Raffaele del Monte Tabor, Italy (CeRMS-UniTO)
NatiMab Therapeuticals SRL, Italy (NatiMab)

Top