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ARC-NET: Centre for Applied Research on Cancer
University of Verona - Policlinico G.B. Rossi
c/o Piastra Odontoiatrica - secondo piano
Piazzale L.A. Scuro, 10,  37134 Verona, Italy

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Project leader

Prof. Aldo Scarpa

Prof. Aldo Scarpa

Phone: +39 045 8027 617
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Project staff

Dr. Andrea Mafficini

Dr. Andrea Mafficini

Phone: +39 045 812 6728
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Dr. Eliana Amato

Dr. Eliana Amato

Phone: +39 045 812 4822
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Dr. Stefania Beghelli

Dr. Stefania Beghelli

Phone: +39 045 812 6728
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Institute presentation

The University Hospital G.B. Rossi is one of the main European Referral Centers for pancreatic cancer. The hospital sees about 1200 new cases each year of which 400 undergo surgical intervention and of which 200 are resections. The majority of these patients participate in a consented program providing tissue, blood and other biological material for research. Basic and translational research projects are coordinated by the ARC-NET research center whose mission is the identification and validation of biomarkers and targets for diagnosis, prognosis and treatment of cancer. This group has over 20 years experience in the collection and preservation of biological material and now boasts a bio-bank of pancreatic tissue and associated material including clinical, pathological, follow-up and specimen associated data. The group has developed in-depth knowledge in xenografting and mouse model development. In particular, they have been among the first to publish in the areas of successful xenografting of cryopreserved primary pancreatic cancers and obtaining novel cell lines and xenograft models also for rare pancreatic tumour types. As part of the Department of Pathology, the group has focused its research on microarray based gene expression profiling and real-time PCR / high throughput immuno-histochemistry validation also using tissue microarrays. The group was the first to carry out the distinct study of the expression profiles of pancreatic neoplastic cells and accompanying stroma, using two methods to separate the cancer cells from the stroma, namely fine needle aspiration and laser capture. The ARC-Net laboratory facilities have all equipment necessary for the execution of the activities indicated in the project. The university has dedicated facilities for mouse experimental modelling and xenografting.

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